JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by GOVIER, WM. M.
Right arrow Articles by BEYER, K. H.
Right arrow Search for Related Content
PubMed
Right arrow Articles by GOVIER, WM. M.
Right arrow Articles by BEYER, K. H.
Journal of Pharmacology And Experimental Therapeutics, Vol. 85, Issue 2, 143-149, 1945
Copyright © 1945 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON THE MECHANISM OF ACTION OF SYMPATHOMIMETIC AMINES

II. THE EFFECT OF SYMPATHOMIMETIC AMINES ON THE SUCCINOXIDASE SYSTEM AS INFLUENCED BY THE PRESENCE OF agr-TOCOPHEROL PHOSPHATE

WM. M. GOVIER 1, VERA BERGMANN 1, and KARL H. BEYER 1

1 From the Department of Pharmacology, The Medical-Research Division, Sharp and Dohme, Inc., Glenolden, Pa.

1. Succinoxidase of homogenized rat muscle and liver is inhibited by added agr-tocopherol phosphate. This effect may be due to diffusion away from the succinoxidase of agr-tocopherol originally present in the tissue, upon rupture of the cells during homogenization.

2. Sympathomimetic amines are capable of producing an increase in oxygen uptake by relieving the tocopherol effect.

3. The increase in metabolic activity following the addition of amines to a tocopherol-inhibited succinoxidase system can be used as a source of energy for the synthesis of cocarboxylase from added thiamin and pyrophosphate.

Submitted on June 25, 1945




This article has been cited by other articles:


Home page
 ScienceHome page
A. Nason and I. R. Lehman
Tocopherol as an Activator of Cytochrome C Reductase
Science, July 1, 1955; 122(3157): 19 - 22.
[PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1945 by the American Society for Pharmacology and Experimental Therapeutics.