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Journal of Pharmacology And Experimental Therapeutics, Vol. 85, Issue 2, 111-118, 1945
Copyright © 1945 by American Society for Pharmacology and Experimental Therapeutics

A SHORT-TERM CHRONIC TOXICITY TEST EMPLOYING MICE

A. C. BRATTON JR. 1

1 From the Department of Pharmacology and Experimental Therapeutics, School of Medicine, The Johns Hopkins University, Baltimore, Md.

A method is described for determining the chronic toxicity of drugs when administered to mice for seven days. The use of the drug-diet method of administration, and of death as an end-point, results in a simple procedure for rapid evaluation of large numbers of compounds. The precision of the method is illustrated by data on quinine, quinacrine, and pamaquine.

Submitted on June 13, 1945




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Copyright © 1945 by the American Society for Pharmacology and Experimental Therapeutics.