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Journal of Pharmacology And Experimental Therapeutics, Vol. 85, Issue 1, 78-84, 1945
Copyright © 1945 by American Society for Pharmacology and Experimental Therapeutics

BIOLOGICAL COMPARISON OF LOCAL ANAESTHETICS

EDITH BÜLBRING 1 and ISABELLA WAJDA 1

1 From the Department of Pharmacology, Oxford

1. Two methods are described for testing the potency of local anaesthetics.

2. With a certain range of concentrations a linear relationship exists between the logarithm of the concentration of the local anaesthetics which were examined and the time at which plexus anaesthesia in frogs develops.

3. When the intracutaneous wheal in guinea-pigs is used, a similar linear relation exists between the logarithm of the concentration of the local anaesthetic and an index expressing both intensity and duration of anaesthesia.

4. The lines for beta-eucaine, procaine and nupercaine, though parallel to each other, are not parallel to that for cocaine. It is suggested, therefore, to use procaine as a standard of comparison. It was observed that when adrenaline was added to procaine and the mixture was compared with cocaine by the guinea-pig method, the log dose-effect lines became parallel.

Submitted on June 12, 1945




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Copyright © 1945 by the American Society for Pharmacology and Experimental Therapeutics.