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Journal of Pharmacology And Experimental Therapeutics, Vol. 85, Issue 1, 74-77, 1945
Copyright © 1945 by American Society for Pharmacology and Experimental Therapeutics

THE HYDROLYSIS OF DEMEROL BY LIVER IN VITRO

FREDERICK BERNHEIM 1 and MARY L. C. BERNHEIM 1

1 From the Department of Physiology and Pharmacology and Department of Biochemistry, Duke University Medical School, Durham, N. C.

1. Demerol is hydrolyzed by the livers of various animals but not by any of the other tissues tested.

2. The hydrolysis is inhibited by eserine and by fluoride.

3. The enzyme responsible for the hydrolysis is distinct from the tropine esterases, cholinesterases, and the esterases which hydrolyze aliphatic esters.

Submitted on June 11, 1945




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