FURTHER OBSERVATIONS ON THE PRESSOR ACTION OF OPTICAL ISOMERS OF SYMPATHOMIMETIC AMINES

¹ From the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis 6, Ind.

1. Of the sympathomimetic drugs, the l-mandelate of optically active aromatic amines appears to be more active in raising the blood pressure of pithed dogs than the d-mandelate of the same isomer, as exemplified by l-ephedrine and other previously reported compounds.

2. No difference in pressor action can be detected between the enantiomorphous mandelates of optically inactive amines, such as -phenylethylamine and tyramine.

3. Neither l- nor d-mandelic acid raises blood pressure.

4. Of the 2-aminoheptane sulfates, the d-isomer having levorotation in water is almost twice as active as the l-isomer, which has a dextrorotation, the dl-isomer being intermediate between the two.

5. Differences in pressor action can be also detected between the enantiomorphous mandelates of d-2-aminoheptane and those of l-2-aminoheptane.