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Journal of Pharmacology And Experimental Therapeutics, Vol. 85, Issue 1, 14-22, 1945
Copyright © 1945 by American Society for Pharmacology and Experimental Therapeutics

ANTITHYROID STUDIES

II. THE GOITROGENIC ACTIVITY OF SOME IMIDAZOLES AND BENZIMIDAZOLES

W. G. BYWATER 1, D. A. McGINTY 1, and N. D. JENESEL 1

1 From the Research Laboratories, Parke, Davis and Company, Detroit, Michigan

Twenty-six compounds belonging to the imidazole or benzimidazole groups have been tested for antithyroid activity. All of these are less active than benzimidazole-2-thiol. Certain relationships between chemical structure and antithyroid activity have been investigated and are discussed in the light of experimental data obtained.

Submitted on May 21, 1945




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 Arch Intern MedHome page
R. H. WILLIAMS and G. A. KAY
THIOURACILS AND THIOUREAS: Comparisons of the Absorption, Distribution, Destruction and Excretion
Arch Intern Med, July 1, 1947; 80(1): 37 - 52.
[Abstract] [PDF]


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Copyright © 1945 by the American Society for Pharmacology and Experimental Therapeutics.