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Journal of Pharmacology And Experimental Therapeutics, Vol. 84, Issue 4, 325-341, 1945
Copyright © 1945 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON SHOCK INDUCED BY HEMORRHAGE

XII. SOME PROPERTIES OF A NATURALLY OCCURRING INHIBITOR OF d-AMINO ACID OXIDASE

MARGARET E. GREIG 1 and WM. E. DE TURK 1

1 From the Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee

The thermolabile, non dialysable inhibitor of d-amino acid oxidase has been further investigated.

It can be precipitated by half saturation with ammonium sulphate and by saturation with magnesium sulphate or sodium chloride.

Adsorption on and elution from cupric hydroxide increases the purity

The solubility properties indicate that it is a globulin like substance

Phosphate in high concentrations inhibits its activity

The activity is greater at low pH's than at high pH's

The combination with d-amino acid oxidase appears to be reversible since a decrease in inhibition is observed when the pH is raised.

Kinetic studies indicate that it does not compete with the coenzyme for the apoenzyme, neither does it compete with the substrate for the apoenzyme-coenzyme complex. It appears to form an apoenzyme-coenzyme-substrate-inhibitor complex.

Submitted on May 10, 1945






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