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In the article by Chance and Lobstein on "The Value of the Guinea-Pig Corneal Reflex for Tests of Surface Anaesthesia" published in this journal, 82, 203, 1944, on page 206 under Volume of Doses, in Dr. Lesser's experiments the anesthetic was injected beneath the conjunctiva. The results then are not comparable to those in which it was applied to the surface and involve passage through an epithelial membrane.