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Journal of Pharmacology And Experimental Therapeutics, Vol. 84, Issue 3, 262-277, 1945
Copyright © 1945 by American Society for Pharmacology and Experimental Therapeutics

FLAVICIN

II: AN ANTIBACTERIAL SUBSTANCE PRODUCED BY AN ASPERGILLUS FLAVUS

MILTON T. BUSH 1, ANDRES GOTH 1, and H. L. DICKISON 1

1 From the Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tenn.

The application of systematic multiple fractional extraction methods and of chromatographic adsorption procedures to the further purification of flavicin is described. Flavicin having activity of 12,000 Staphylococcus Dilution Units per mg. (800 Oxford Units/mg.) has been obtained by both methods. This material is probably not yet pure. The toxicity in mice of specimens of flavicin having 200-300 Oxford U./mg. is so low that 1000 mg./kg. intraperitoneally produce almost no symptoms. Some pharmacological effects of flavicin are described, including beneficial results in two human patients suffering from Staphylococcus septicemia.

Flavicin and penicillin, both purified by the same method to an activity of 500 Oxford Units per mg., are very similar in their chemical and antibiotic properties. Further studies of more nearly pure specimens will be required to demonstrate whether they are identical or not.

Submitted on April 16, 1945




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Copyright © 1945 by the American Society for Pharmacology and Experimental Therapeutics.