THE ABSORPTION AND EXCRETION OF SOLUTHIAZOLE AND SOLUPYRIDINE

¹ From the Biological Division, May & Baker, Ltd., Dagenham, London

The absorption and excretion of soluthiazole and solupyridine have been studied in animals and in man.

When injected intravenously, subcutaneously or intramuscularly, they provide a means of rapidly obtaining a high concentration in the blood, and the peak concentration occurred usually within half-an-hour. They are present in the blood almost entirely in the free form, very little being conjugated. There was little difference between the rates of absorption of soluthiazole and solupyridine either in animals or in man. The concentration in the cerebrospinal fluid was much lower than in blood.

Excretion in the urine was rapid, and in the series of human cases examined from 40 to 75 per cent of the dose was excreted within 12 hours. The amounts conjugated were less than 10 per cent.