STUDIES ON THE GENERAL PHARMACOLOGY OF DIBUTOLINE

¹ Department of Pharmacology, College of Medicine, State University of Iowa, Iowa City

Dibutoline has been shown to have favorable antispasmodic effects on smooth muscle when given by injection, but to be effective in oral doses, over 30 mgm./kgm. must be administered. It has been shown to be more effective in overcoming or blocking the stimulation or inhibition of smooth muscle due to neurotropic drugs, like acetylcholine, than in overcoming or blocking the action of musculo-stimulating drugs, like barium chloride. The mode of action of dibutoline appears to be similar to that of atropine.