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Journal of Pharmacology And Experimental Therapeutics, Vol. 84, Issue 1, 64-66, 1945
Copyright © 1945 by American Society for Pharmacology and Experimental Therapeutics

PHENOL CONJUGATION

IV. EFFECT OF SEVERAL INHIBITORS

R. H. DEMEIO 1 and R. I. ARNOLT 1

1 Department of Physiology and Pharmacology, Duke University School of Medicine, Durham, N. C., and Department of Pharmacology, Rosario Medical School, Rosario, Argentina

1. 0.002 M monoiodoacetate inhibits phenol conjugation in rat (Vanderbilt strain), guinea-pig, dog (puppy), and cat liver, which is not reestablished by addition of glucuronate.

2. Phenol conjugation is also inhibited by 0.01 M azide, octyl alcohol, 0.005 M fluoride, 0.0003 M bisulfite and partially by 0.02 M sodium oxalate.

3. Lack of magnesium and presence of citrate have no effect on conjugation.

Submitted on February 26, 1945






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