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Journal of Pharmacology And Experimental Therapeutics, Vol. 84, Issue 1, 34-41, 1945
Copyright © 1945 by American Society for Pharmacology and Experimental Therapeutics

STUDIES OX THE ESTIMATION, ADSORPTION AND PRECIPITATION OF STILBAMIDINE

J. D. FULTON 1 and T. W. GOODWIN 1

1 From Liverpool School of Tropical Medicine and Department of Biochemistry, University of Liverpool

1. A spectrophotometric method has been described for the estimation of stilbamidine in serum.

2. The drug-levels in the sera of mice treated by the oral, subcutaneous, intraperitoneal and intravenous routes were estimated at intervals over periods of forty-eight hours. The drug was rapidly absorbed, the peak values occurring in all cases within 30 minutes after administration. At the end of two hours only minute amounts were present.

3. No unequivocal evidence was obtained for the adsorption of the drug from solution by suspensions of red blood cells.

4. A series of precipitation reactions with solutions of the drug and various reagents has been described.

Submitted on February 7, 1945






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Copyright © 1945 by the American Society for Pharmacology and Experimental Therapeutics.