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Journal of Pharmacology And Experimental Therapeutics, Vol. 84, Issue 1, 16-25, 1945
Copyright © 1945 by American Society for Pharmacology and Experimental Therapeutics

THE PHARMACOLOGICAL PROPERTIES OF SOME MONOAMIDINES

L. G. GOODWIN 1 and P. B. MARSHALL 1

1 From the Wellcome Laboratories of Tropical Medicine, 183 Euston Road, London, England

1. Some pharmacological properties of a series of 36 monoamidines have been studied.

2. None of these compounds had any action upon infections of Trypanosoma equiperdum or Trypanosoma cruzi in mice, and a few selected compounds were inactive against hamster leishmaniasis and canary malaria.

3. Pyridyl monoamidines in general showed respiratory stimulation and analeptic activity in anaesthetised animals.

4. Most of the monoamidines caused a fall of blood pressure upon intravenous injection, had spasmolytic activity, and also produced a depression of the kneejerk reflex.

5. It is unlikely that any of the compounds would he of value in therapeutics.

Submitted on December 22, 1944






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