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Journal of Pharmacology And Experimental Therapeutics, Vol. 83, Issue 4, 288-293, 1945
Copyright © 1945 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON ANTIMALARIAL DRUGS

THE DISTRIBUTION OF ATABRINE IN THE TISSUES OF THE FOWL AND THE RABBIT

FRANCES K. OLDHAM 1 and F. E. KELSEY 1

1 Department of Pharmacology, University of Chicago

The accumulation and persistence of atabrine in the tissues of the fowl and rabbit has been studied after single and repeated intravenous injections.

Atabrine was found to be more rapidly eliminated in the fowl than in the rabbit.

In the rabbit atabrine is stored in highest concentration in the lung, kidney, spleen, adrenal and liver. However, when organ weights are taken into consideration, the greatest amount of atabrine is generally stored in the liver. In the chicken, little atabrine is stored in the lungs and with the exception of the liver, all organs store less atabrine than do those of the rabbit.

The intravenous toxicity of atabrine is approximately three times greater in the rabbit than in the fowl.

Atabrine traverses the placenta of the pregnant rabbit and becomes stored in the fetal tissues.

Submitted on January 26, 1945






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Copyright © 1945 by the American Society for Pharmacology and Experimental Therapeutics.