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Journal of Pharmacology And Experimental Therapeutics, Vol. 83, Issue 4, 275-278, 1945
Copyright © 1945 by American Society for Pharmacology and Experimental Therapeutics

METABOLISM, TOXICITY, AND MANNER OF ACTION OF GOLD COMPOUNDS IN THE TREATMENT OF ARTHRITIS

VII. THE EFFECT OF VARIOUS GOLD COMPOUNDS ON THE OXYGEN CONSUMPTION OF RAT TISSUES

WALTER D. BLOCK 1 and ELIZABETH L. KNAPP 1

1 From the Rackham Arthritis Research Unit, Medical School, University of Michigan, Ann Arbor

1. The in vitro effect of various gold-containing compounds upon the oxygen consumption of liver and kidney slices from healthy white rats was determined.

2. The oxygen consumption was inhibited by the inorganic, ionizable compounds, gold chloride and gold sodium thiosulfate, and to a lesser degree by colloidal gold sulfide. The organic, non-ionizable compounds, sodium succinimido-aurate, gold sodiumn thiomalate, and gold thioglucose, did not cause any inhibition. At equal molar concentrations of gold the degree of inhibition was greater for kidney than for liver slices.

3. Solutions of gold chloride varying in ionic concentration from M/250 to M/5000 produced the same relative degree of inhibition on the oxygen consumption of liver and kidney slices.

4. The significance of these findings in relation to earlier studies on the distribution of gold in tissues is discussed briefly.

Submitted on January 26, 1944






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Copyright © 1945 by the American Society for Pharmacology and Experimental Therapeutics.