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Journal of Pharmacology And Experimental Therapeutics, Vol. 83, Issue 4, 265-269, 1945
Copyright © 1945 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF HEPATOTOXIC ALKALOIDS ON THE PROTHROMBIN TIME OF RATS

CHARLES L. ROSE 1, ROBERT D. FINK 1, PAUL N. HARRIS 1, and K. K. CHEN 1

1 From the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis

1. Senecionine, retrorsine, pterophine, spartioidine, and monocrotaline, in sufficient doses, prolong the plasma prothrombin time of rats. Sceleratine has a similar effect, but to a less degree.

2. Retronecine, retronecic lactone, and monocrotalic acid—the degradation products of retrorsine and monocrotaline—do not cause liver necrosis in mice and rats, or hypoprothrombinemia in rats.

3. Feeding of a vitamin K preparation, menadione, to rats appears to inhibit the hypoprothrombinemic action of retrorsine and monocrotaline.

4. Variation of the protein content of the diet and addition of brewer's yeast and liver extract have no appreciable effect upon the hypoprothrombinemic action of senecionine.

Submitted on January 20, 1945




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Copyright © 1945 by the American Society for Pharmacology and Experimental Therapeutics.