JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by BLUMENFELD, S.
Right arrow Articles by LOEWI, O.
Right arrow Search for Related Content
PubMed
Right arrow Articles by BLUMENFELD, S.
Right arrow Articles by LOEWI, O.
Journal of Pharmacology And Experimental Therapeutics, Vol. 83, Issue 1, 96-99, 1945
Copyright © 1945 by American Society for Pharmacology and Experimental Therapeutics

DIGITALIS AND CALCIUM

S. BLUMENFELD 1 and O. LOEWI 1

1 From Departments of Pharmacology and Therapeutics, New York University, College of Medicine

1. Medium and large doses of digitalis applied in Ringer solution have after a short while a systolic effect, minimal effective doses after a long time, a diastolic effect.

2. Raising the calcium concentration after large doses of digitalis increases, after small doses decreases the systolic action.

3. The immediate action of increased calcium content of the Ringer solution on the normal heart consists in an increase of the systolic contraction, the prolonged action in a decrease.

4. Systolic or diastolic standstill of the heart as produced by digitalis cannot be produced by the application of high calcium concentration on the normal heart.

5. The mode of the interaction of digitalis and calcium is discussed.






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1945 by the American Society for Pharmacology and Experimental Therapeutics.