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Journal of Pharmacology And Experimental Therapeutics, Vol. 83, Issue 1, 90-95, 1945
Copyright © 1945 by American Society for Pharmacology and Experimental Therapeutics

THE ANTI-HISTAMINE ACTIVITY OF DIETHYLAMINOETHYL-DIHYDROANTHRACENE-CARBOXYLATE AND OTHER SUBSTANCE

GERHARD LEHMANN 1 and JAMES W. YOUNG 1

1 From the Department of Pharmacology, University of Louisville School of Medicine, Louisville, Ky.

Diethylaminoethyl-dihydroanthracene-carboxylate provides 100 per cent protection to sensitized guinea pigs against one fatal dose of antigen. Diethylaminoethyl-xanthene-carboxylate is 70 per cent effective. Diethylaminoethyl-fluorene-carboxylate, aminophylline and epinephrine protect only 37 per cent of the animals.

The dihydroanthracene derivative reduces the volume but not the acid concentration of histamine-induced gastric secretion.

The dihydroanthracene derivative intensified the intradermal skin reaction produced by histamine.

The increase in the resistance of the pulmonary circulation of the isolated perfused guinea pig's lung caused by epinephrine, histamine or anaphylactic reaction, is reduced by aminophylline and the dihydroanthracene derivative. The latter is more potent in its bronchodilator effect than aminophylline.

The possibility that the main mechanism of aminophylline in bronchial asthma is the decrease in the resistance of the pulmonary circulation, is suggested.

Submitted on October 26, 1944




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Copyright © 1945 by the American Society for Pharmacology and Experimental Therapeutics.