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Journal of Pharmacology And Experimental Therapeutics, Vol. 83, Issue 1, 53-55, 1945
Copyright © 1945 by American Society for Pharmacology and Experimental Therapeutics

DISTRIBUTION OF TUNGSTEN IN THE RAT FOLLOWING INGESTION OF TUNGSTEN COMPOUNDS

F. W. KINARD 1 and J. C. AULL 1

1 From the Departments of Physiology and Chemistry, Medical College of the State of South Carolina, Charleston, South Carolina

In rats kept for 100 days on diets in which tungsten had been incorporated as either the metal, tungstic oxide, sodium tungstate, or ammonium paratungstate, the chief sites of deposition were bone and spleen, with smaller quantities in the skin, kidney, and liver. The possibility that the finding of tungsten in the skin is an artefact is discussed.

Traces of the element were found in some instances in blood, lung, muscle, and testis. In only a single instance was tungsten found in the brain, heart, or uterus.

In no case was tungsten found in any of the tissues of the control animals.

Submitted on November 15, 1944




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L. S. Keith, D. B. Moffett, Z. A. Rosemond, and D. W. Wohlers
ATSDR evaluation of health effects of tungsten and relevance to public health
Toxicology and Industrial Health, June 1, 2007; 23(5-6): 347 - 387.
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Copyright © 1945 by the American Society for Pharmacology and Experimental Therapeutics.