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Journal of Pharmacology And Experimental Therapeutics, Vol. 82, Issue 3, 324-329, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

N1-DIMETHYLACROYL SULPHANILAMIDE (IRGAMID)

S. T. CALLENDER M.B., CH.B.1 and J. F. POWELL B.Sc.1

1 Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford

1. The concentration of N1-dimethylacroyl sulphanilamide (irgamid) in the blood and cerebro-spinal fluid and the excretion in the urine have been studied after various methods of administration.

2. High blood concentrations can be easily reached and maintained, and with smaller doses than are required with sulphapyridine or sulphanilamide.

3. The toxic effects in the cases studied were practically negligible—this may be correlated with the relatively small degree of acetylation. The drug is readily absorbed and well tolerated by the intramuscular route.

4. There is reason to believe, however, that the therapeutic efficiency is not high.

Submitted on August 29, 1944






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Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.