JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by BEYER, K. H.
Right arrow Articles by VERWEY, W. F.
Right arrow Search for Related Content
PubMed
Right arrow Articles by BEYER, K. H.
Right arrow Articles by VERWEY, W. F.
Journal of Pharmacology And Experimental Therapeutics, Vol. 82, Issue 3, 310-323, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

THE ENHANCEMENT OF THE PHYSIOLOGICAL ECONOMY OF PENICILLIN IN DOGS BY THE SIMULTANEOUS ADMINISTRATION OF PARA-AMINOHIPPURIC ACID II

KARL H. BEYER 1, LAWRENCE PETERS 1, ROLAND WOODWARD 1, and W. F. VERWEY 1

1 From the Departments of Pharmacology and Bacteriology, The Medical-Research Division, Sharp and Dohme, Inc. Glenolden, Penna.

It has been found that the continuous infusion of sodium p-aminohippurate facilitates a physiological economy by the body of single intravenous injections of penicillin. When compared with similar experiments, wherein penicillin but no p-aminohippuric acid was injected, the effectiveness of the latter agent may be judged by: 1) the prolonged maintenance of a determinable plasma concentration of penicillin, 2) a marked prolongation of the period of time over which penicillin was excreted, 3) a definite descrease in the rate of excretion of penicillin, and 4) a marked decrease in the amount of penicillin recovered in the urine in a given period of time.

It was concluded that the manner in which this effect has been produced was by a competition between p-aminohippuric acid and penicillin for excretion by the renal tubular epithelium. This appeared to be the case, since the renal clearance of penicillin, which normally approximates the renal plasma flow of dogs, can be depressed to or below that measuring glomerular filtration rate by the simultaneous administration of sodium p-aminohippurate intravenously to maintain a plasma concentration that causes its own clearance to be less than maximal.

Submitted on August 16, 1944




This article has been cited by other articles:


Home page
 ScienceHome page
K. H. BEYER
New Concept of Competitive Inhibition of the Renal Tubular Excretion of Penicillin
Science, January 24, 1947; 105(2717): 94 - 95.
[Abstract] [PDF]

Home page
 ScienceHome page
A. H. FREE, R. F. PARKER, and B. E. BIRO
ORAL PENICILLIN--A COMPARISON OF VARIOUS MODES OF ADMINISTRATION
Science, December 28, 1945; 102(2661): 666 - 668.
[Abstract] [PDF]

Home page
 ScienceHome page
B. A. HOUSSAY, O. ORIAS, and I. SARA
THE MECHANISM OF ACTION OF ALLOXAN ON BLOOD SUGAR
Science, August 24, 1945; 102(2643): 197 - 197.
[PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.