PHARMACOLOGIC STUDIES OF A NEW VASOCONSTRICTOR: 2-NAPHTHYL-(1')-METHYL-IMIDAZOLINE HYDROCHLORIDE (PRIVINE OR NAPHTHAZOLINE)

II. VASCULAR AND RESPIRATORY REACTIONS IN THE ANESTHETIZED DOG

¹ Department of Pharmacology, Wayne University College of Medicine, Detroit, Michigan

1. Privine elevates the blood pressure in the anesthetized dog in doses of the same order of magnitude as required for epinephrine but to a lesser extent.

2. Privine is partially inhibited but not reversed by yohimbine and ethyl yohimbine; it is not potentiated by cocaine; it infrequently exhibits tachyphylaxis and then only to a slight degree.

3. Privine administered gastrically or rectally in large doses reveals no systemic evidences of absorption. Relatively large doses administered nasally, intraperitoneally, or within the ileum, exhibit minimal systemic changes.

4. Privine may be synergistic with sodium pentobarbital in its depressive action on respiration but no evidence of such depression in dogs anesthetized with ether or urethane could be elicited.

5. The margin of safety for Privine is high since 5 micrograms is an effective dose and 1 mg. failed to kill the animal.

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