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Journal of Pharmacology And Experimental Therapeutics, Vol. 82, Issue 3, 247-253, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

THE NEUTRALIZATION OF GASTRIC ACIDITY WITH BASIC ALUMINUM AMINOACETATE

JOHN C. KRANTZ JR.1, DOROTHY V. KIBLER 1, and FREDERICK K. BELL 1

1 From the Department of Pharmacology, School of Medicine, University of Maryland, Baltimore, Md.

1. A new compound, the basic aluminum salt of aminoacetic acid, has been prepared.

2. Its capacity to buffer and neutralize hydrochloric acid has been studied. Its prompt and prolonged buffering of acid, bespeaks the use of the compound in the treatment of hyperacidity and peptic ulcer. On the basis of the aluminum content, basic aluminum aminoacetate is 42 per cent more efficient in acid-consuming power than dried aluminum hydroxide gel.

3. Certain theoretical considerations of its use have been discussed.

4. Feeding studies on rats and preliminary clinical trials as an antacid in man are recorded.

Submitted on August 4, 1944




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J. C. KRANTZ JR., W. E. EVANS JR., and J. G. MCALPINE
ORAL PENICILLIN WITH BASIC ALUMINUM AMINOACETATE
Science, June 15, 1945; 101(2633): 618 - 619.
[Abstract] [PDF]


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Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.