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Journal of Pharmacology And Experimental Therapeutics, Vol. 82, Issue 2, 120-132, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

OBSERVATIONS BEARING ON THE MECHANISM OF THE ELIMINATION OF QUININE AND ATABRINE FROM THE CIRCULATION AND TISSUES

GRAHAM CHEN 1 and E. M. K. GEILING 1

1 From the Department of Pharmacology, The University of Chicago

A simple, rapid and accurate procedure was devised for the determination of quinine and its fluorescent degradation products in blood and tissues.

The rate at which atabrine and quinine leaves the circulation following intravenous injection has been determined in chickens after partial blockage of the reticulo-endothelial system; in dogs with hepatic injury; in rabbits with leukopenia, and following evisceration, and in heart-lung preparations. In all cases, the alkaloid disappeared rapidly as in normal animals. The seat of elimination was found to be the capillaries, principally of the lung.

In heart-lung preparations there was no indication of any destruction of the injected atabrine for at least one hour, while 70 per cent of the injected quinine was destroyed enzymatically in 5 minutes. With the diminution of the quantity of quinine, there was a correspondingly increased amount of its fluorescent degradation products in the blood and tissues.

Submitted on June 27, 1944






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Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.