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Journal of Pharmacology And Experimental Therapeutics, Vol. 82, Issue 1, 98-102, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

COMPARISON OF ESTERS OF STROPHANTHIDIN IN CATS

FRANK A. STELDT 1, ROBERT C. ANDERSON 1, and K. K. CHEN 1

1 From the Lilly Research Laboratories, Indianapolis, Indiana

Strophanthidin-3-acetate, -diethylaminoacetate, -propionate, and -n-caproate are more powerful than the parent aglycone, strophanthidin, as shown in cats. By slow intravenous injection, strophanthidin-dichloroacetate and -iso-caproate appear to be equally as active as strophanthidin. Esters with acids beyond 6 C-atoms, in the series studied, have a lower activity than strophanthidin. A few members of the series with lower molecular weights are effectively absorbed in dogs following oral administration.

Submitted on July 28, 1944






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Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.