SOME CIRCULATORY EFFECTS OF PRIVINE HYDROCHLORIDE

¹ From the Department of Pharmacology, University of Texas Medical Branch, Galveston

Circulatory effects of privine HCl on intravenous injection are compared with those of some sympathomimetic amines. In dogs narcotized with pentobarbital, the minimal pressor dose is 1-2 x 10^–5 mM./kg., while a maximum response is usually obtained with 5 x 10^–5 to 10^–4 mM./kg. Above this dose, privine generally causes cardiac irregularities which limit the pressor response. Tachyphylaxis occurs at about this dose. Atropine and cocaine do not appreciably influence the action of privine; 933F reduces but does not reverse the pressor action. Small doses of privine potentiate epinephrine but large doses are adrenolytic. Cheynes-Stokes' respiration often follows injection of large doses.