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Journal of Pharmacology And Experimental Therapeutics, Vol. 81, Issue 4, 402-407, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

COMPARATIVE ANTICONVULSIVE ACTION OF 3,5,5-TRIMETHYLOXAZOLIDINE-2,4-DIONE (TRIDIONE), DILANTIN AND PHENOBARBITAL

GUY M. EVERETT 1 and RICHARD K. RICHARDS 1

1 Department of Pharmacology, Abbott Laboratories, North Chicago, Illinois

1. The marked antagonistic action of 3,5,5-trimethyloxazolidine-2,4-dione (Tridione) against convulsions produced by drugs and electrical shock has been demonstrated in experimental animals.

2. Comparative experiments with phenobarbital and dilantin revealed that tridione is more comparable to phenobarbital in its action but produces less depression in effective doses.

Submitted on June 12, 1944






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Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.