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Journal of Pharmacology And Experimental Therapeutics, Vol. 81, Issue 4, 390-401, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

STREPTOTHRICIN AS A CHEMOTHERAPEUTIC AGENT

HARRY J. ROBINSON and DOROTHY G. SMITH

1. In vitro and in vivo studies show that crude streptothricin possesses marked activity against a variety of gram-negative bacterial species. Gram-positive forms are also sensitive to the action of streptothricin, but not to the same degree as the gram-negative form.

2. The activity of streptothricin is not influenced by blood, serum, peptone, or vitamins of the B complex.

3. Streptothricin is more active when given parenterally than when administered by mouth.

4. The drug is not active against the virus of epidemic influenza or Trypanosoma equiperdum.

5. The ultimate chemotherapeutic index of streptothricin will depend upon the toxicity of the pure product.

6. The results suggest that streptothricin may be useful in the local treatment of infected wounds and burns, as well as bacillary dysentery, typhoid fever and food poisoning produced by the Salmonella organisms.

Submitted on June 7, 1944




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Science, July 13, 1945; 102(2637): 34 - 35.
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J. FRIED and O. WINTERSTEINER
CRYSTALLINE REINECKATES OF STREPTOTHRICIN AND STREPTOMYCIN
Science, June 15, 1945; 101(2633): 613 - 615.
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Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.