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Journal of Pharmacology And Experimental Therapeutics, Vol. 81, Issue 4, 374-377, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

THE OXIDATION IN VITRO OF MORPHINE BY RAT LIVER SLICES

FREDERICK BERNHEIM 1 and MARY L. C. BERNHEIM 1

1 From the Departments of Physiology and Pharmacology and of Biochemistry, Duke University Medical School, Durham, N. C.

1. Morphine added to rat liver slices is oxidized apparently at the hydroxy groups. Kidney and brain are inactive.

2. The reaction does not occur under anaerobic conditions or after boiling the slices. Liver cell suspensions oxidize morphine much more slowly than slices.

3. No evidence of conjugation was found.

4. Dilaudid is also oxidized under the same conditions.

5. Codeine and dionine apparently inhibit the oxidation of morphine.

Submitted on May 18, 1944




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Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.