SOME COMPARATIVE PHARMACOLOGICAL ACTIONS OF BETAHYDROXY AND METHOXY PHENYL-n-PROPYLAMINES

¹ From the Research Laboratories, The Upjohn Company, Kalamazoo, Michigan

1. A complete series of -phenyl-n-propylamines were studied pharmacologically with respect to their actions on the dogs blood pressure, isolated rabbits lung and acute intravenous toxicity in rats.

2. In general, the methoxy derivatives of this series were better bronchodilators than their corresponding hydroxyl analogues. Also, as a rule they were more toxic intravenously in rats.

3. In general, the hydroxy derivatives were more potent pressor substances than their corresponding methoxy analogues.

4. There appears to be a definite relationship between pressor action and naso-mucous membrane vasoconstriction as measured by the nasograph mirror method of Lieb and Mulinos (14).

5. No relationships could be demonstrated between bronchiolar and pressor actions.