JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by UNNA, K.
Right arrow Articles by PICK, E. P.
Right arrow Search for Related Content
PubMed
Right arrow Articles by UNNA, K.
Right arrow Articles by PICK, E. P.
Journal of Pharmacology And Experimental Therapeutics, Vol. 81, Issue 3, 294-300, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

INHIBITION OF NERVOUS TRANSMISSION IN SYNAPSES AND END PLATES BY THIAMINE

K. UNNA 1 and E. P. PICK 1

1 From the Merck Institute for Therapeutic Research, Rahway, New Jersey, and the Mount Sinai Hospital, New York, New York

1. Thiamine (5-15 mgm. per 100 cc.) inhibits the action of nicotine in the isolated intestine of rabbits and guinea pigs. Cocarboxylase has the same effect as thiamine. The action of drugs stimulating sympathetic or parasympathetic nerve endings is not influenced by thiamine.

2. This effect of thiamine is linked to the thiazole moiety of the thiamine molecule and appears to be analogous to the effect of certain sulfonamides.

3. Thiamine also inhibits the action of nicotine in the striated muscle of frogs.

4. The effect of thiamine upon the nicotine action is not influenced by prostigmine.

5. The processes involved in the inhibition of the nicotine action in synapses and in end plates at the myoneural junction are discussed.

Submitted on May 24, 1944




This article has been cited by other articles:


Home page
 Arch SurgHome page
A. STEINDLER
PROGRESS IN ORTHOPEDIC SURGERY FOR 1944 A Review Prepared by an Editorial Board of the American Academy of Orthopaedic Surgeons: XXII. Research
Arch Surg, March 1, 1946; 52(3): 377 - 385.
[Abstract] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.