THE ACUTE TOXICITY FOR MICE OF "MAPHARSEN" AND SODIUM SULFATHIAZOLE ADMINISTERED SEPARATELY AND IN COMBINATION

¹ From the Departments of Pharmacology and Zoology of the University of Minnesota, Minneapolis, Minnesota and the Department of Dermatology, College of Medicine, University of Illinois, Chicago, Illinois

1. Under the experimental conditions described, the LD₅₀ of an intraperitoneally administered 0.3% aqueous solution of "Mapharsen" (3-amino-4-hydroxyphenylarsine oxide hydrochloride, administered as the sodium salt) in young "Strain A" mice, was found to be 34.0 ± 0.5 mgm. per kg.

2. The LD₅₀ of a 10% aqueous solution of sodium sulfathiazole administered similarly, was found to be 1.32 ± 0.02 grams per kgm.

3. The combined toxicity of "Mapharsen" and sodium sulfathiazole was found to be greater than the toxicity of either drug alone, since the LD₅₀ of the combination was 65 per cent of the LD₅₀ of each drug alone.

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