JPET Celsis microsomes equal better data

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by WAY, E. L.
Right arrow Articles by CHAN, L. K.
Right arrow Search for Related Content
PubMed
Right arrow Articles by WAY, E. L.
Right arrow Articles by CHAN, L. K.
Journal of Pharmacology And Experimental Therapeutics, Vol. 81, Issue 3, 278-283, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

THE TOXICITY AND TRYPANOCIDAL ACTIVITY OF p-SULFONAMIDOPHENYLARSONIC ACID AND CERTAIN OF ITS DERIVATIVES

E. LEONG WAY 1 and L. K. CHAN 1

1 From the Department of Pharmacology, The George Washington University, School of Medicine, Washington, D. C., and the Department of Pharmacology, University of California, School of Medicine, San Francisco, Calif.

1. The toxicity of p-sulfonamidophenylarsonic acid, its derivatives, and of propamidine are reported.

2. The tolerated dose of p-sulfonamidophenylarsonic acid in mice was found to be 1900 mgm./kgm. and the curative dose 700 mgm./kgm.

3. Propamidine was found to be tolerated at 40 mgm./kgm. and curative at 5 mgm./kgm.

4. None of the N substituted derivatives of p-sulfonamidophenylarsonic acid showed trypanocidal activity.

5. A discussion of the biochemorphology of the compounds is included.

Submitted on May 4, 1944






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.