JPET Celsis microsomes equal better data

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Journal of Pharmacology And Experimental Therapeutics, Vol. 81, Issue 3, 240-247, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON SHOCK INDUCED BY HEMORRHAGE VIII. THE INACTIVATION OF THE APOENZYME OF AMINO ACID OXIDASE AND LACTIC DEHYDROGENASE IN ANOXIA

MARGARET E. GREIG 1

1 From the Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee

1. Tissues which have been made anoxic show a decreased ability to metabolize lactic and amino acids.

2. This decreased oxidative ability is not due entirely to coenzyme destruction nor to an anaerobic accumulation of intermediate metabolites which inhibit oxidation.

3. A heat labile, non-dialyzable, enzyme like substance has been found in tissue extracts which inhibits lactic and amino acid oxidation. It is assumed that this is the same factor which inhibits oxidation in anoxic tissue.

4. This enzyme like substance appears to attack the apoenzyme or protein part of the oxidative enzyme systems.

Submitted on April 10, 1944






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Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.