JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by GOODWIN, L. G.
Right arrow Search for Related Content
PubMed
Right arrow Articles by GOODWIN, L. G.
Journal of Pharmacology And Experimental Therapeutics, Vol. 81, Issue 3, 224-234, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

THE TOXICITY AND TRYPANOCIDAL ACTIVITY OF SOME ORGANIC ANTIMONIALS

L. G. GOODWIN 1

1 From the Wellcome Bureau of Scientific Research, 183, Euston Road, London, N. W. 1

1. A series of tervalent and quinquevalent organic antimonials has been tested for toxicity, irritancy and trypanocidal activity, and the results assessed by accurate methods.

2. Trypanocidal activity has been determined by two methods, one depending upon the removal of trypanosomes from the peripheral blood, and the other upon the survival times of infected mice. Differences have been observed between the results in the case of phenyl stibonic acid derivatives.

3. The properties investigated are shown to be independent of antimony content, but to have some correlation with one another and with the initial rate of excretion of the antimony.

Submitted on March 2, 1944






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.