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Journal of Pharmacology And Experimental Therapeutics, Vol. 81, Issue 3, 218-223, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

A DISTRIBUTION METHOD FOR THE DIFFERENTIATION OF URINARY EXCRETION PRODUCTS OF THE SULFONAMIDE DRUGS AND THE ROLE OF THESE PRODUCTS IN UROLITHIASIS

JOHN V. SCUDI 1 and VIOLA C. JELINEK 1

1 From the Research Laboratories of Merck & Co., Inc.

The urinary excretion products of a number of sulfonamide drugs have been divided, by means of a distribution method, into a so-called organic-soluble group and a water-soluble group. The products within each group have been considered and their relationship to the incidence of sulfonamide urolithiasis has been discussed.

Of the "free" sulfonamide (i.e., not including acetyl derivatives) found in the urine, it has been estimated that 40 per cent of the sulfapyridine; 10 to 20 per cent of the sulfanilamide, sulfathiazole and sulfamerizine; and 4 to 6 per cent of the sulfadiazine and sulfapyrazine exists in the form of water-soluble metabolites. The diminution of these values parallels the pK values of the heterocyclic sulfonamides.

Submitted on February 11, 1944






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Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.