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Journal of Pharmacology And Experimental Therapeutics, Vol. 81, Issue 2, 203-208, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

AN EVALUATION OF THE INFLUENCE OF SUCCINATE AND MALONATE ON BARBITURATE HYPNOSIS

KARL H. BEYER 1 and ALBERT R. LATVEN 1

1 From the Department of Pharmacology, The Medical-Research Division, Sharp and Dohme, Inc., Glenolden, Pa.

Sodium malonate and glutamate, as administered in these experiments, were without effect on the duration of pentobarbital hypnosis in mice or rats. We were able to confirm the observation that pentobarbital did not inhibit the in vitro oxidation of succinate by the succinoxidase system. Though it was found that the intramuscular administration of sodium succinate to mice and rats moderately diminished the duration of pentobarbital hypnosis, this succinate-barbiturate antagonism was not nearly as great on a dosage basis as has been reported previously.

Submitted on March 29, 1944






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Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.