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Journal of Pharmacology And Experimental Therapeutics, Vol. 81, Issue 2, 197-202, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

RELATIONSHIP OF CHEMICAL STRUCTURE OF SYMPATHOMIMETIC AMINES TO VENTRICULAR TACHYCARDIA DURING CYCLOPROPANE ANESTHESIA

O. S. ORTH 1, J. W. STUTZMAN 1, and WALTER J. MEEK 1

1 From the Departments of Pharmacology and Physiology, University of Wisconsin Medical School, Madison

Fifteen additional sympathomimetic amines have been tested for their ability to produce ventricular tachycardia in the dog during cyclopropane anesthesia. In a dosage producing a blood pressure rise equal to that caused by 0.01 mgm. of adrenalin per kilogram, the six primary and secondary amines with a catechol nucleus consistently elicited ventricular tachycardia. Tertiary amines with a catechol nucleus and the other amines used did not cause this irregularity.

Submitted on March 27, 1944






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Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.