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Journal of Pharmacology And Experimental Therapeutics, Vol. 81, Issue 2, 164-173, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON SHOCK INDUCED BY HEMORRHAGE VII. THE DESTRUCTION OF COZYMASE AND ALLOXAZINE ADENINE DINUCLEOTIDE IN TISSUES DURING SHOCK

MARGARET E. GREIG 1

1 From the Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee

1. Changes in cozymase and alloxazine adenine dinucleotide are found to occur in muscle, liver and brain when the animal is subjected to hemorrhage.

2. Brain is apparently the first tissue to show the effect of hemorrhage since decreases in cozymase and alloxazine adenine dinucleotide are most frequent in this tissue.

3. Animals requiring large amounts of bleeding to produce shock showed less destruction of cozymase than did animals which went into shock with small amounts of bleeding.

4. Administration of nicotinic acid and riboflavin may result in a resynthesis of the respective coenzymes.

Submitted on February 23, 1944




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Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.