PLASMA CONCENTRATIONS FOLLOWING THE ORAL ADMINISTRATION OF SINGLE DOSES OF THE PRINCIPAL ALKALOIDS OF CINCHONA BARK

¹ Physiology Department of New York University College of Dentistry

1. Studies of the plasma concentrations, after taking oral doses of quinine, quinidine, cinchonidine, cinchonine, and Totaquina, were made using normal dental students as subjects.

2. With equivalent doses there are marked differences in the plasma concentrations reached after taking different cinchona alkaloids. Quinine gives the highest concentrations, cinchonidine and quinidine next, while cinchonine gives very low plasma concentration.

3. The plasma concentration after administering Totaquina is about what would be expected from the additive effect of the constituents.

4. The plasma concentration of any of the alkaloids is markedly lower if the dose is administered immediately after a meal.

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