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Journal of Pharmacology And Experimental Therapeutics, Vol. 81, Issue 2, 133-141, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

INHIBITORY EFFECT OF SULFONAMIDES ON THE ACTION OF NICOTINE IN THE ISOLATED INTESTINE

E. P. PICK 1, G. W. BROOKS 1, and K. UNNA 1

1 From the Laboratories of the Mount Sinai Hospital, New York, N. Y. and the Merck Institute for Therapeutic Research, Rahway, N. J.

1. Sulfonamides inhibit the effect of nicotine on the isolated intestine of rabbits and guinea pigs.

2. Sodium sulfathiazole, sodium sulfamerazine and sulfanilamide are more effective in inhibiting the action of nicotine than sodium sulfadiazine.

3. Para aminobenzoic acid fails to antagonize the effect of sulfonamides upon the action of nicotine.

4. The effect of adrenalin, acetylcholine, lentin, prostigmine, histamine, and barium chloride on the isolated intestine is not influenced by sulfonamides.

5. Sulfathiazole does not influence the toxic manifestations of nicotine in frogs, nor does it inhibit the action of nicotine upon the striated muscle of the frog.

Submitted on February 7, 1944






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Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.