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Journal of Pharmacology And Experimental Therapeutics, Vol. 81, Issue 1, 84-94, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

AMIDES, AMINES AND RELATED COMPOUNDS AS DIURETICS

WERNER L. LIPSCHITZ 1 and ZAREH HADIDIAN 1

1 From The Lederle Laboratories, Pearl River, N. Y.

1. Seventy amides, amines, amidines, urea, pyrimidine and purine derivatives and amino derivatives of the cyanuric acid were tested by the rat assay method for diuretic action. Melamine, adenine and formoguanamine were found to be potent diuretics.

2. The dependency of diuretic activity upon chemical structure was discussed, and some view-points of diuretic action presented.

Submitted on December 2, 1943




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Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.