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Journal of Pharmacology And Experimental Therapeutics, Vol. 81, Issue 1, 77-83, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF TYROSINASE ON PHENETHYLAMINE DERIVATIVES

LOWELL O. RANDALL 1 and GEORGE H. HITCHINGS 1

1 The Wellcome Research Laboratories, Tuckahoe, N. Y.

The initial rate of oxidation of a series of phenethylamine derivatives as catalyzed by tyrosinase has been studied.

The primary and secondary derivatives of any series were oxidized more rapidly than the tertiary and quaternary derivatives.

The 3,4-dihydroxyphenethylamines were oxidized more rapidly than the 2,3-dihydroxy derivatives or epinephrine.

The 4-hydroxyphenethylamines were oxidized more rapidly than the 3-hydroxyphenethylamine. The 2-hydroxy and unsubstituted phenethylamines, and the N-substituted 3-hydroxy derivatives were not oxidized at all.

There was no correlation of ease of oxidation with the physiological activity of the amines.

Submitted on August 10, 1943






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Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.