ANESTHETIC ACTIVITY OF THE CIS-TRANS ISOMERS OF TRICHLOROETHYLIDENE GLYCEROL

¹ From the Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee

Trichloroethylidene glycerol has been separated into the two component cistrans isomers (each a racemic modification). These have been tested on mice in comparison with tribromoethanol. Both isomers produce a quiet anesthesia of brief duration, and they are nearly equal in activity. They are little less active as anesthetics both by the intravenous and by the intraperitoneal route than is tribromoethanol, but their lethal doses by both routes are conspicuously higher than the corresponding values for tribromoethanol.