JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by CANTONI, G. L.
Right arrow Articles by LOEWI, O.
Right arrow Search for Related Content
PubMed
Right arrow Articles by CANTONI, G. L.
Right arrow Articles by LOEWI, O.
Journal of Pharmacology And Experimental Therapeutics, Vol. 81, Issue 1, 67-71, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

INHIBITION OF CHOLINESTERASE ACTIVITY OF NERVOUS TISSUES BY ESERINE IN VIVO

G. L. CANTONI 1 and O. LOEWI 1

1 From Department of Pharmacology, New York University College of Medicine

1. The acetylcholine present in the central nervous system and in the peripheral nerves is completely or almost completely hydrolyzed during grinding and subsequent incubation of the tissues.

2. Subcutaneous injection of eserine even in large doses does not affect this process in the case of the central nervous system.

3. In contrast to this the acetylcholine of peripheral nerves is completely protected from hydrolysis by subcutaneous injection of eserine.

4. Propagation of impulses in such nerves is present.

Submitted on January 10, 1944






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.