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Journal of Pharmacology And Experimental Therapeutics, Vol. 81, Issue 1, 10-16, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

THE ROLE OF PYROGENS IN THE ALLEGED LEUKOCYTIC RESPONSE TO ALLANTOIN

E. GORDON YOUNG 1 and W. W. HAWKINS 1

1 From the Department of Biochemistry, Dalhousie University, Halifax, Canada

The effects of administering allantoin orally and parenterally to man, dog and rabbit have been tested experimentally with relation to total white cell and differential counts.

No effect from single or repeated oral doses of 0.26 to 7.35 gm. has been demonstrated. Marked leukocytosis with neutrophilia within 3 to 5 hours has been observed in eleven human male subjects after intravenous and subcutaneous administration of doses from 50 to 240 mgm. in Ringer's solution. These effects have been shown to be due to pyrogenic substances in the solvent medium. Pure allantoin in sterile saline made up from double-distilled water was without any effect on man.

The use of leukocytosis as a test for pyrogens is suggested in relation to intravenous therapy.

Submitted on November 29, 1943






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Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.