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Journal of Pharmacology And Experimental Therapeutics, Vol. 81, Issue 1, 1-9, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

THE ABSORPTION AND EXCRETION OF ALLANTOIN IN MAMMALS

E. GORDON YOUNG 1, HELEN P. WENTWORTH 1, and W. W. HAWKINS 1

1 From The Department of Biochemistry, Dalhousie University, Halifax, Canada

Allantoin administered to dogs orally as solid or solution was excreted in the urine to an extent of between 35 and 92 per cent within 24 hours. No allantoin was recovered either in urine or feces when given to rabbits orally. In man the recovery was 19 and 34 per cent in two individuals after massive doses.

After intravenous administration recovery in the urine was practically quantitative with doses of 75 to 600 mgm. in the dog and in man. After 240 mgm. in man excretion continued for 72 hours. The results were similar after subcutaneous injection.

Uric acid injected intravenously into a dog was converted into allantoin within two hours.

Submitted on November 29, 1943






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