STUDIES ON THE DETOXICATION OF ORGANIC ARSENICAL COMPOUNDS V. ADDITIONAL DETOXICANTS FOR PENTAVALENT ARSENICALS

¹ Lilly Research Laboratories, Indianapolis, Indiana

Continuing studies previously reported, it is here shown that many aromatic compounds have the property of inhibiting the lethal consequence of massive doses (ca. L.D. 90+) of pentavalent aromatic arsenicals in rats. In addition to the three isomeric forms of aminobenzoic acid, a high order of protection is conferred by the hydroxy- and nitro-analogues of PABA, as well as by other substituted compounds which are readily soluble and not in themselves highly toxic to the test animal. Inasmuch as benzoic, phenyl acetic, and phenyl propionic acids are all highly effective, it appears that a high degree of structural similarity between detoxicant and toxicant is not an essential of the mechanism underlying the detoxication phenomenon.

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				C. F. MOHR, V. SCOTT, R. D. HAHN, E. G. CLARK, and J. E. MOORE SYPHILIS: REVIEW OF THE RECENT LITERATURE Arch Intern Med, November 1, 1944; 74(5): 390 - 411. [Abstract] [PDF]