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Journal of Pharmacology And Experimental Therapeutics, Vol. 80, Issue 4, 383-385, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON ANTIMALARIAL DRUGS

THE EXCRETION OF ATABRINE IN THE URINE OF THE HUMAN SUBJECT

F. E. KELSEY 1, F. K. OLDHAM 1, E. H. DEARBORN 1, M. SILVERMAN 1, and E. W. LEWIS 1

1 From the Departments of Pharmacology and Biochemistry, University of Chicago

The daily urinary excretion of atabrine was studied in four subjects receiving 100 mgm. per day for 45 days. The amount excreted rose slowly throughout the experiment but in no case exceeded 11% of the daily dose Fifty-five days after the last dose appreciable amounts of atabrine were present in the urine. All subjects showed mild toxic symptoms.

Submitted on December 29, 1943






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Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.